Executive dysfunction predicts treatment response to neuroplasticity-based computerized cognitive remediation (nCCR-GD) in elderly patients with major depression

摘要

ObjectivesExecutive dysfunction (ED) is a predictor of poor treatment response of late-life depression to pharmacotherapy. In response to the consistency of these findings, we designed a neuroplasticity-based computerized cognitive remediation (nCCR-GD) intervention to target and improve ED in patients who failed to remit with antidepressant treatment. This study tests the hypothesis that ED at baseline will predict favorable treatment response to nCCR-GD.