Human stem cell-derived hepatocytes as a model for hepatitis B virus infection spreading and virus-host interactions

摘要

Background and AimsOne major obstacle of hepatitis B virus (HBV) research is the lack of efficient cell culture system permissive for viral infection and replication. The aim of our study was to establish a robust HBV infection model by using hepatocyte-like cells (HLCs) derived from human pluripotent stem cells.