Adhesion G-Protein Coupled Receptors and Extracellular Matrix Proteins: Roles in Myelination and Glial Cell Development

摘要

BackgroundAdhesion G protein-coupled receptors (aGPCRs) are a large family of transmembrane proteins that play important roles in many processes during development, primarily through cell-cell and cell-extracellular matrix (ECM) interactions. In the nervous system, they have been linked to the complex process of myelination, both in the central and peripheral nervous system.