The contribution of the TP53 R337H mutation to the cancer burden in Southern Brazil: Insights from the study of 55 families of children with adrenocortical tumors

摘要

BackgroundThe TP53 R337H mutation predisposes children to adrenocortical tumors (ACT) and, rarely, to other childhood tumors, but its impact on adult cancer remains undetermined. This study investigated the frequency and types of cancer in relatives of children with ACT who carry the TP53 R337H mutation.