Exogenous expression of Drp1 plays neuroprotective roles in the Alzheimers disease in the Aβ42 transgenic Drosophila model

摘要

BackgroundAlzheimer's disease (AD) is one of the most common neurodegenerative disorders. Recent studies have shown that mitochondrial dysfunction is a causative factor of AD. Drp1 (Dynamin-related protein 1), a regulator of mitochondrial fission, shows neuroprotective effects on Parkinson’s disease. In this study, we investigate the effect and mechanism of Drp1 on Aβ42 transgenic Drosophila.