Interaction between nonsteroidal anti-inflammatory drugs and low-fatdietary intervention on colorectal cancer incidence; the Women’s HealthInitiative (WHI) Dietary Modification Trial

摘要

Background:The Women’s Health Initiative (WHI) Dietary Modification (DM) trial did not show that reductions in dietary fat accompanied by increases in vegetable and fruit consumption decreases the incidence of colorectal cancer. Secondary analyses suggested that aspirin use may modify the intervention effects of DM on colorectal cancer development, although a recent re-analysis including the post-intervention period confirmed no main effect of the intervention on reducing colorectal cancer incidence