Intermittent access to ethanol drinking facilitates the transition to excessive drinking after chronic intermittent ethanol vapor exposure

摘要

BackgroundAlcohol binge drinking in humans is thought to increase the risk for alcohol use disorder. Unclear is whether drinking patterns (e.g., binge-like or stable drinking) differentially affect the transition to compulsive-like drinking in dependent individuals. We examined whether chronic binge-like drinking facilitates the transition to compulsive-like drinking in rats.