Non-linear imputation of PaO2/FIO2 from SpO2/FIO2 among mechanically ventilated patients in the intensive care unit: a prospective observational study

摘要

ObjectivesIn the contemporary intensive care unit (ICU), mechanically ventilated patients may not have arterial blood gas (ABG) measurements available at relevant timepoints. Severity criteria often depend on ABG results. Retrospective studies suggest that non-linear imputation of PaO2/FIO2 from SpO2/FIO2 is accurate, but this has not been established prospectively among mechanically ventilated ICU patients. The objective was to validate the superiority of non-linear imputation of PaO2/FIO2 among mechanically ventilated patients and understand what factors influence the accuracy of imputation.