Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye

摘要

BackgroundNotch signaling is broadly required during embryogenesis, frequently activating the transcription of two bHLH transcription factors, Hes1 and Hes5. But, it remains unresolved when and where Hes1 and Hes5 act alone or together during development. Here, we analyzed a Hes5-GFP BAC transgenic mouse, as a proxy for endogenous Hes5. We directly compared transgenic GFP expression with Hes1, and particular markers of embryonic lens and retina development.