Layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

摘要

A chip-based platform for laser desorption/ionization mass spectromatry (LDI-MS) analysis of small molecules was developed by utlizing layer-by-layer (LBL) assemmbly of MoS2 nanoflake and polyallyamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 film exhibit high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distributions, and its performance was further enhaced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.