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Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells

机译：细胞类型特定的染色质签名强调人类诱导的多能干细胞和体细胞中的调控DNA元素。

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摘要

RationaleRegulatory DNA elements in the human genome play important roles in determining the transcriptional abundance and spatiotemporal gene expression during embryonic heart development and somatic cell reprogramming. It is a mystery how chromatin marks in regulatory DNA elements are modulated to establish cell type-specific gene expression in the human heart.

机译：原理人类基因组中的调控DNA元素在确定胚胎心脏发育和体细胞重编程过程中的转录丰度和时空基因表达中起重要作用。调节性DNA元件中的染色质标记如何在人的心脏中建立细胞类型特异性基因表达，这是一个谜。

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期刊名称 other
作者
Ming-Tao Zhao; Ning-Yi Shao; Shijun Hu; Ning Ma; Rajini Srinivasan; Fereshteh Jahanbani; Jaecheol Lee; Sophia L. Zhang; Michael P. Snyder; Joseph C. Wu;
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年(卷),期 -1(121),11
年度 -1
页码 1237–1250
总页数 28
原文格式 PDF
正文语种
中图分类
关键词
Human iPSCs endothelial cells cardiac progenitor cells Fibroblasts Regulatory DNA elements stem cell epigenetics histone markers;

机译：人iPSC;内皮细胞;心脏祖细胞;成纤维细胞;调控DNA元件;干细胞;表观遗传学;组蛋白标记;

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专利

1. Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells [J] . Zhao Ming-Tao, Shao Ning-Yi, Hu Shijun, Circulation research: a journal of the American Heart Association . 2017,第11期

机译：特异性特异性染色质签名在人诱导的多能干细胞和体细胞中下划线调节DNA元素
2. Systematic evaluation of markers used for the identification of human induced pluripotent stem cells Systematic evaluation of markers used for the identification of human induced pluripotent stem cells Systematic evaluation of markers used for the identification of human induced pluripotent stem cells [J] . Alok Srivastava, Shaji Ramachandran Velayudhan, Kannan Vrindavan Manian, Biology Open . 2017,第1期

机译：用于鉴定人诱导多能干细胞的标志物的系统评价用于鉴定人诱导多能干细胞的标志物的系统评价用于鉴定人诱导多能干细胞的标志物的系统评价
3. Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes [J] . Disheet Shah, Kim Larsson, Jukka Kuusela, Biology Open . 2017,第6期

机译：低细胞外钾可延长人诱导的多能干细胞来源的心肌细胞的复极化，并引起早期去极化。低细胞外钾可延长人诱导的多能干细胞来源的心肌细胞的重新极化并引起去极化的早期。低细胞外钾可使人多能干细胞诱导的复极化并引起早期去极化细胞源性心肌细胞
4. Immortalised human skin fibroblast feeder cells support growth and maintenance of human embryonic stem cells and induced pluripotent stem cells [C] . Christian Unger, Shuping Gao, Marie Cohen, World Congress on In Vitro Fertilization . 2009

机译：永生化人皮肤成纤维细胞饲养细胞支持人胚胎干细胞的生长和维持和诱导多能干细胞
5. Polycistronic lentiviral vector for hit and run reprogramming of mouse and human somatic cells to induced pluripotent stem cell. [D] . Chang, Chia-Wei. 2009

机译：多顺反子慢病毒载体，用于将小鼠和人类体细胞命中和运行重编程为诱导性多能干细胞。
6. Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex cell type-specific landscape with novel regulatory elements [O] . Jennifer M. Taylor, Kate Wicks, Claire Vandiedonck, 2008

机译：跨人类肿瘤坏死因子基因位点的染色质分析揭示了具有新型调控元件的复杂细胞类型特异性景观
7. Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells [O] . Ming-Tao Zhao, Ning-Yi Shao, Shijun Hu, 2017

机译：特异性特异性染色质签名在人诱导的多能干细胞和体细胞中下划线调节DNA元素

Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells

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