Sevoflurane acts on ubiquitination-proteasome pathway to reduce postsynaptic density 95 levels in young mice

摘要

BackgroundChildren with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane, a commonly used anesthetic in children, has been reported to decrease levels of postsynaptic density protein 95 (PSD-95). However, the up-stream mechanisms and down-stream consequences of the sevoflurane-induced reduction in PSD-95 levels remains largely unknown. We therefore set out to assess whether sevoflurane acts on ubiquitination-proteasome pathway to facilitate PSD-95 degradation.