Urine metabolic ratio of omeprazole in relation to CYP2C19 polymorphisms in Russian peptic ulcer patients

机译：俄罗斯消化性溃疡患者中奥美拉唑的尿代谢率与CYP2C19基因多态性的关系

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摘要

BackgroundCYP2C19 is known to be the main enzyme of biotransformation of proton pump inhibitors (PPIs), whereas the CYP2C19 gene is highly polymorphic. Genotyping and phenotyping together represent more reliable data about patient’s CYP2C19 activity.

机译：背景技术已知CYP2C19是质子泵抑制剂（PPI）生物转化的主要酶，而CYP2C19基因是高度多态的。基因分型和表型共同代表有关患者CYP2C19活性的更可靠数据。

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期刊名称 Pharmacogenomics and Personalized Medicine
作者
Natalia P Denisenko; Dmitriy A Sychev; Zhanna M Sizova; Valeriy V Smirnov; Kristina A Ryzhikova; Zhannet A Sozaeva; Elena A Grishina;
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作者单位

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年(卷),期 2017(10),-1
年度 2017
页码 253–259
总页数 7
原文格式 PDF
正文语种
中图分类药学;
关键词
pharmacogenetics phenotyping metabolomics proton pump inhibitor;

机译：药物遗传学;表型;代谢组学;质子泵抑制剂;

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专利

1. Urine metabolic ratio of omeprazole in relation to CYP2C19 polymorphisms in Russian peptic ulcer patients [J] . Natalia P Denisenko, Dmitriy A Sychev, Zhanna M Sizova, Pharmacogenomics and Personalized Medicine . 2017,第3期

机译：俄罗斯消化性溃疡患者中奥美拉唑的尿代谢率与CYP2C19基因多态性的关系
2. CYP3A and CYP2C19 activity in urine in relation to CYP3A4, CYP3A5, and CYP2C19 polymorphisms in Russian peptic ulcer patients taking omeprazole [J] . Natalia P Denisenko, Dmitriy A Sychev, Zhanna M Sizova, Pharmacogenomics and Personalized Medicine . 2018,第4期

机译：俄罗斯服用奥美拉唑的消化性溃疡患者尿中CYP3A和CYP2C19活性与CYP3A4，CYP3A5和CYP2C19多态性的关系
3. The frequency of CYP2C19 genetic polymorphisms in Russian patients with peptic ulcers treated with proton pump inhibitors [J] . DA Sychev, NP Denisenko, ZM Sizova, Pharmacogenomics and Personalized Medicine . 2015,第1期

机译：质子泵抑制剂治疗俄罗斯消化性溃疡患者CYP2C19基因多态性的频率
4. On the use of Bayesian network classifiers to classify patients with peptic ulcer among upper gastrointestinal bleeding patients [C] . Aisha Nazziwa, Adam Mohd Bakri 2012 International Conference on Statistics in Science, Business, and Engineering. . 2012

机译：关于使用贝叶斯网络分类器对上消化道出血患者中消化性溃疡患者进行分类
5. The dynamics of intergovernmental relations in a developing federal system: The Russian Federation in the 1990s. [D] . Mazur, Paul. 2004

机译：政府间关系在不断发展的联邦体系中的动态：1990年代的俄罗斯联邦。
6. CYP3A and CYP2C19 activity in urine in relation to CYP3A4 CYP3A5 and CYP2C19 polymorphisms in Russian peptic ulcer patients taking omeprazole [O] . Natalia P Denisenko, Dmitriy A Sychev, Zhanna M Sizova, 2018

机译：俄罗斯服用奥美拉唑的消化性溃疡患者尿中CYP3A和CYP2C19活性与CYP3A4CYP3A5和CYP2C19多态性的关系
7. The frequency of CYP2C19 genetic polymorphisms in Russian patients with peptic ulcers treated with proton pump inhibitors [O] . Natalia Denisenko, Dmitrij Sychev, Zhanna Sizova, 2015

机译：用质子泵抑制剂治疗的消化性溃疡患者CYP2C19遗传多态性的频率
8. Study to Determine the Changes of Physician Prescribing Patterns of AntimicrobialAgents, Omeprazole and H2-Receptor Antagonists for Peptic Ulcer Disease Two Years Following the NIH Consensus Conference on 'H. Pylori' [R] . Thamer, M., Ray, N. F., Henderson, S., 1997

机译：在美国国立卫生研究院共识会议之后两年，确定消化性溃疡病的抗菌药物，奥美拉唑和H2受体拮抗剂的医师处方模式变化的研究幽门螺杆菌”

Urine metabolic ratio of omeprazole in relation to CYP2C19 polymorphisms in Russian peptic ulcer patients

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