Regional vulnerability in Alzheimer’s: The role of cell-autonomous and transneuronal processes

摘要

INTRODUCTIONThe stereotypical progression of Alzheimer’s (AD) pathology is not fully understood. The selective impact of AD on distinct regions has led the field to question if innate vulnerability exists. This study aims to determine if the causative factors of regional vulnerability are dependent on cell-autonomous or transneuronal (non-cell autonomous) processes.