The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac Skeletal and Vascular Smooth Muscle Cells

摘要

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic free Ca²⁺ concentration increase due to a rapid Ca²⁺ release from intracellular stores and a transmembrane Ca²⁺ influx, mainly through L-type Ca²⁺ channels. Compelling evidences have demonstrated that Ca²⁺ might also enter through other cationic channels such as Store-Operated Ca²⁺ Channels (SOCCs), involved in several physiological functions and pathological conditions. The opening of SOCCs is regulated by the filling state of the intracellular Ca²⁺ store, the sarcoplasmic reticulum, which communicates to the plasma membrane channels through the Stromal Interaction Molecule 1/2 (STIM1/2) protein. In muscle cells, SOCCs can be mainly non-selective cation channels formed by Orai1 and other members of the Transient Receptor Potential-Canonical (TRPC) channels family, as well as highly selective Ca²⁺ Release-Activated Ca²⁺ (CRAC) channels, formed exclusively by subunits of Orai proteins likely organized in macromolecular complexes. This review summarizes the current knowledge of the complex role of Store Operated Calcium Entry (SOCE) pathways and related proteins in the function of cardiac, skeletal, and vascular smooth muscle cells.