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Microparticles Formed During Storage of Red Blood Cell Units Support Thrombin Generation

机译:红细胞单位储存过程中形成的微粒支持凝血酶生成

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摘要

BACKGROUNDIntact red blood cells (RBCs) appear to support thrombin generation in in vitro models of blood coagulation. During storage of RBC units, biochemical, structural and physiological changes occur including alterations to RBC membranes and release of microparticles, which are collectively known as storage lesion. The clinical consequences of microparticle formation in RBC units are unclear. This study was performed to assess thrombin generation via the prothrombinase complex by washed RBCs and RBC-derived microparticles as a function of RBC unit age.
机译:背景技术在体外凝血模型中,完整的红细胞(RBC)似乎支持凝血酶的产生。在RBC单位的存储过程中,会发生生化,结构和生理变化,包括RBC膜的改变和微粒的释放,这些统称为存储病变。 RBC单位中微粒形成的临床后果尚不清楚。进行这项研究是为了评估洗涤后的RBC和RBC衍生的微粒通过凝血酶原酶复合物产生的凝血酶,与RBC单位年龄有关。

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