Gene Expression Profiles of Ion Channels and Receptors in Mouse Resistance Arteries: Effects of Cell Type Vascular Bed and Age

摘要

ObjectiveReceptors and ion channels of smooth muscle cells (SMCs) and endothelial cells (ECs) are integral to the regulation of vessel diameter and tissue blood flow. Physiological roles of ion channels and receptors in skeletal muscle and mesenteric arteries have been identified however their gene expression profiles are undefined. We tested the hypothesis that expression profiles for ion channels and receptors governing vascular reactivity vary with cell type, vascular bed and age.