Polynucleotide, recombinant genetic construct, expression vector, host cell, transgenic animal, peptide, methods for screening an agent for pharmacological activity, inhibiting the binding of gnrh to its native receptor in vivo, and contraception, and uses of type ii gnrh-r or an extracellular domain thereof

摘要

POLYNUCLEOTIDE, RECOMBINANT GENETIC CONSTRUCTION, EXPRESSION VECTOR, HOST CELL, TRANSGENIC ANIMAL, PEPTIDE, METHODS FOR SCREENING AN AGENT, PHARMACOLOGICAL ACTIVITY, INHIBITION OF THE INCEPTION AND GON INPRODUCTION, GnRH-R OF TYPE II OR AN EXTRACELLULAR DOMAIN. Polynucleotides encoding the full sequence for marmoset and human Type II gonadotropin releasing hormone receptor (GnRH-R Type II) are provided. Corresponding amino acid sequences are also provided.