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Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice

机译：靶向p75神经营养因子受体改善小鼠脊髓损伤引起的逼尿肌括约肌功能障碍

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AimsTo determine the role of p75 neurotrophin receptor (p75^NTR) and the therapeutic effect of the selective small molecule p75^NTR modulator, LM11A-31, in spinal cord injury (SCI) induced lower urinary tract dysfunction (LTUD) using a mouse model.

机译：目的确定p75神经营养蛋白受体（p75 ^{NTR ）的作用以及选择性小分子p75 ^{NTR 调节剂LM11A-31在脊髓损伤（SCI）中的治疗作用使用小鼠模型诱发下尿路功能障碍（LTUD）。}}

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期刊名称 other
作者
Irina V. Zabbarova; Youko Ikeda; Evan J. Carder; Peter Wipf; Amanda S. Wolf-Johnston; Lori A. Birder; Naoki Yoshimura; Samuel E. Getchell; Khalifa Almansoori; Pradeep Tyagi; Christopher H. Fry; Marcus J. Drake; Anthony J. Kanai;
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年(卷),期 -1(37),8
年度 -1
页码 2452–2461
总页数 17
原文格式 PDF
正文语种
中图分类
关键词
LM11A-31 lower urinary tract dysfunction/symptoms (LUTD/LUTS) neurodegeneration neurogenic bladder dysfunction proneurotrophins;

机译：LM11A-31;下尿路功能障碍/症状（LUTD / LUTS）;神经退行性疾病;神经源性膀胱功能障碍;前神经营养素;

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专利

1. Targeting p75 neurotrophin receptors ameliorates spinal cord injury‐induced detrusor sphincter dyssynergia in mice [J] . Zabbarova Irina V., Ikeda Youko, Carder Evan J., Neurourology and urodynamics. . 2018,第8期

机译：靶向p75神经养殖受体改善脊髓损伤诱导的小鼠的毒细胞括约肌Dyssynergia
2. IVERMECTIN-INDUCED ACTIVATION OF MUTANT GLYCINE RECEPTORS DELIVERED TO A Delta-FIBER BLADDER AFFERENTS BY HERPES SIMPLEX VIRUS VECTORS DRIVEN BY A SUBPOPULATION-SPECIFIC NEUROFILAMENT PROMOTER IMPROVES DETRUSOR-SPHINCTER DYSSYNERGIA AND INEFFICIENT VOIDING IN MICE WITH SPINAL CORD INJURY [J] . Saito T., Shimizu N., Goins W., Neurourology and urodynamics. . 2019,第Suppla3期

机译：伊维菌素诱导由由亚潜疱疹特异性神经丝促进剂驱动的单纯疱疹病毒载体递送至δ-纤维囊引起的突变甘氨酸受体的活化改善了脊髓损伤小鼠的尿布 - 括约肌疼痛和低效的排尿
3. Combined Detrusor and External Urethral Sphincter BTX-A Injections for Detrusor Overactivity and Detrusor External Sphincter Dyssynergia Secondary to Spinal Cord Injury [J] . Maping Huang, Heyi Zhen, Tianhai Huang, Open Journal of Urology . 2021,第2期

机译：结合沥青和外尿尿渣括约肌BTX - 用于脊髓损伤的排尿管过度育和逼尿肌外括约肌的注射
4. Molecular modeling of the interaction of neurotrophins with the P75~NTR common neurotrophin receptor [C] . Igor L.Shamovsky, Gregory M.Ross, Richard J.Riopelle, Annual international high performance computing systems and applications symposium . 2000

机译：神经营养素与P75〜NTR常见神经营养素受体相互作用的分子模拟
5. Recovery of the detrusor - external urethral sphincter coordination after incomplete spinal cord injury [D] . Pikov, Victor E. 2000

机译：脊髓不完全损伤后逼尿肌-外尿道括约肌协调性的恢复
6. Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase in spinal cord injures rats [O] . Minoru Miyazato, Kimio Sugaya, Seiichi Saito, -1

机译：通过疱疹病毒载体介导的脊髓酸脱羧酶递疱疹病毒载体介导的基因递送抑制尿布 - 括约肌失调性失育蛋白酶损伤大鼠
7. Botulinum A toxin as a treatment of detrusor- sphincter dyssynergia in patients with spinal cord injury: MRI controlled transperineal injections [O] . Schurch, B., Hodler, J., Rodic, B. 1997

机译：肉毒杆菌毒素治疗逼尿肌括约肌脊髓损伤患者的神经痛：MRI控制经会阴注射

Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice

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