Nicotine metabolite ratio predicts smoking topography: The Pennsylvania Adult Smoking Study

摘要

Background:The nicotine metabolite ratio (NMR) as measured by the ratio of 3′hydroxycotinine to cotinine has been examined in relation to tobacco use patterns including cigarettes per day and quit success to determine its role in nicotine dependence. We examined the NMR in relation to smoking topography and tested the hypothesis that normal metabolizers have a greater total daily puff volume than slow metabolizers.