Spirazabicyclical heterocyclic compound, pharmaceutical composition, use of a compound, and, treatment processes or prophylaxis of human diseases or conditions in which the activation of the nicotinic alpha7 receptor is beneficial, of psychotic disorders or disorders of intellectual weakening and imbalance of the normal circadian rhythm due to subsonic or supersonic travel, smoking cessation, nicotine addiction, pain and ulcerative colitis and preparation of a compound

摘要

"SPIROAZABICYCLIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, AND, TREATMENT PROCESSES OR PROPHYLAXIS OF HUMAN DISEASES OR CONDITIONS IN WHICH THE ALPHETIC DETECTOR OF THE HYDROPHIC NICHETRIC DETECTOR IS DEFECTIVE, DEFICIENTAL HISTORICAL DETECTIONS. NORMAL DUE TO SUBSYNIC OR SUPERSONIC TRAVEL, SMOKING CESSATION, NICOTIN VICE, PAIN AND ULCERATIVE COLITIS AND PREPARATION OF A COMPOUND ". A compound of formula (I) where n is 0 or 1; m is 0 or 1; p is 0 or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H ~ 2 ~ or F ~ 2 ~; A is N or C (R²); G is N or C (R³); D is N or C (R ^ 4 ^); with the proviso that no more than one of A, G and D is nitrogen, but at least one of Y, A, G and D is nitrogen or NO; R. is hydrogen or C ~ 1 ~ to C ~ 4 ~ alkyl; R², R³ and R ^ 4 ^ are independently hydrogen, halogen, C ~ 1 ~ -C ~ 4 ~ alkyl, C ~ 2 ~ -C ~ 4 ~ alkenyl, C ~ 2 ~ -C ~ 4 ~ alkyl, aryl, heteroaryl , OH, OC ~ 1 ~ -C ~ 4 ~ alkyl, CO ~ 2 ~ R ~ 1 ~, -CN, -NO ~ 2 ~, -NR ^ 5 ^ R ^ 6 ^, -CF ~ 3 ~, -OSO ~ 2 ~ CF ~ 3 ~ or R² and R³, or R³ and R ^ 4 ^, respectively, can together form another six-membered aromatic or heteroaromatic ring A and G, or G and D, respectively, containing between zero and two nitrogen atoms, and replaced by one to two of the following substituents; independently hydrogen, halogen, C ~ 1 ~ -C ~ 4 ~ alkyl, C ~ 2 ~ -C ~ 4 ~ alkaline, C ~ 2 ~ -C ~ 4 ~ alkynyl, aryl, heteroaryl, OH, OC ~ 1 ~ - alkyl C ~ 4 ~, CO ~ 2 ~ R ~ 1 ~, -CN, -NO ~ 2 ~, -NR ^ 5 ^ R ^ 6 ^, -CF ~ 3 ~, -OSO ~ 2 ~ CF ~ 3 ~; R ^ 5 ^ and R ^ 6 ^ are independently hydrogen, C ~ 1 ~ -C ~ 4 ~ alkyl, C (O) R ^ 7 ^, C (O) NHR ^ 8 ^, C (O) OR ^ 9 ^ , SO ~ 2 ~ R ^ 10 ^, or together can be (CH ~ 2 ~) ~ j ~ Q (CH ~ 2 ~) ~ k ~, where Q is O, S, NR ^ 11 ^ or a bond ; j is 2 to 7, k is 0 to 2; R ^ 7 ^, R ^ 8 ^, R ^ 9 ^, R ^ 10 ^ and R ^ 11 ^ are independently C ~ 1 ~ -C ~ 4 ~ alkyl, aryl or heteroaryl, or an enantiomer thereof, and their salts pharmaceutically acceptable, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.