TCR-δ Expression and γδ+ T-cell Infiltrates in Primary Cutaneous Gamma-delta T-cell Lymphoma and other Cutaneous T-cell Lymphoproliferative Disorders

摘要

AimsThe diagnosis of cutaneous gamma delta T-cell lymphoma (GDTCL) requires the identification of γδ chains of the T-cell receptor (TCR). Using a new mAb to TCRδ, we evaluated TCRδ expression in formalin fixed paraffin embedded (FFPE) skin tissue from TCRγ-positive cutaneous T-cell lymphoma (CTCL) and assessed TCRδ expression within a spectrum of other cutaneous lymphoproliferative disorders (CLPD).