High Throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-Hypnotics

摘要

BackgroundMany general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered. We hypothesized that a sedative-hypnotic screening approach using zebrafish larvae responses to sensory stimuli would perform comparably to standard assays, and efficiently identify new active compounds.