Asmic: An exceptional building block for isocyanide alkylations

摘要

Asmic addresses the long-standing challenge of alkylating isocyanides, providing access to isocyanides with diverse substitution patterns. The o-anisylsulfanyl group serves a critical dual role by facilitating deprotonation-alkylation and in providing a latent nucleophilic site through an unusual arylsulfanyl-lithium exchange.