PATH-20. ANAPLASTIC ASTROCYTOMA: WHY DOES SURVIVAL DIFFER SO MUCH FOR THE SAME HISTOLOGICAL GRADE?

摘要

BACKGROUNDIncreasing knowledge and understanding of the molecular genetics driving both the occurrence and transformation of gliomas has led to a more discrete and objective classification of such tumours. Both phenotypic and genotypic variations now underpin their classification, and thus help to more accurately guide their clinical management. However, WHO Grade III Anaplastic Astroyctoma (AA) remains an unpredictable, heterogeneous entity; displaying a variable prognosis, clinical course and treatment response. AIMS: To examine additional measurable tumour characteristics that may delineate overall survival (OS) more predictably in AA.