Four New Furostanol Saponins from the Rhizomes and Roots of Smilax scobinicaulis and Their Cytotoxicity

摘要

Four new furostanol saponins >1–>4, along with two known furostanol saponins >5 and >6 and one known spirostanol saponin >7 were isolated from the rhizomes and roots of Smilax scobinicaulis. The structures of the new saponins were elucidated as 26-O-β-d-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one-3-O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside (>1), 26-O-β-d-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one (>2), 26-O-β-d-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-20(22)-en-6-one (>3), 26-O-β-d-glucopyranoside-3β,23,26-trihydroxy-(23R, 25R)-5α-furostan-20(22)-en-6-one (>4) on the basis of spectroscopic analysis. The isolated saponins were evaluated for cytotoxic activity against two human cancer cell lines including Hela (cervical carcinoma) and SMMC-7221 (hepatocellular carcinoma). Compounds >1 and >7 demonstrated cytotoxicity against the tested cell lines.