Design synthesis and antibacterial potential of 5-(benzod13dioxol-5-yl)-3-tert-butyl-1-substituted-45-dihydropyrazoles

摘要

A series of 5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-1-substituted-4,5-dihydropyrazole derivatives >4a–e and >6a–g have been synthesized and spectrally characterized. The antibacterial activity of the novel candidates has been screened using the agar diffusion test. These compounds were endowed with high antibacterial activity against different Gram +ve and Gram −ve bacteria when compared with standard antibacterial drugs. In the light of zone of inhibition and MIC results, Sarcina and Staphylococcus aureus are the most sensitive bacteria where pyrrolidinomethanone derivative >4e showed MICs at 80 and 110 nM, respectively. While hydroxypiperidinoethanone derivative >6c showed MIC at 90 nM for Sarcina.