Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed

机译：人源抗炭疽保护性抗原中和单克隆抗体来自接种炭疽疫苗的供体

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BackgroundPotent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors. The anti-anthrax toxin human monoclonal antibodies were evaluated for neutralization of anthrax lethal toxin in vivo in the Fisher 344 rat bolus toxin challenge model.

机译：背景技术强大的炭疽毒素中和人单克隆抗体是从炭疽疫苗吸附（AVA）免疫供体获得的外周血淋巴细胞中产生的。在Fisher 344大鼠推注毒素攻击模型中评估了抗炭疽毒素人单克隆抗体的体内炭疽致死毒素的中和作用。

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期刊名称 Journal of Immune Based Therapies and Vaccines
作者
Ritsuko Sawada-Hirai; Ivy Jiang; Fei Wang; Shu Man Sun; Rebecca Nedellec; Paul Ruther; Alejandro Alvarez; Diane Millis; Phillip R Morrow; Angray S Kang;
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作者单位

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年(卷),期 2004(2),-1
年度 2004
页码 5
总页数 15
原文格式 PDF
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中图分类免疫学;
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专利

1. Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed [J] . Ritsuko Sawada-Hirai, Ivy Jiang, Fei Wang, Journal of Immune Based Therapies Vaccines . 2004,第4期

机译：人源抗炭疽保护性抗原中和单克隆抗体，来自接种炭疽疫苗的供体
2. Evaluation of sex, race, body mass index and pre-vaccination serum progesterone levels and post-vaccination serum anti-anthrax protective immunoglobulin G on injection site adverse events following anthrax vaccine adsorbed (AVA) in the CDC AVA human clinical trial [J] . Pondo Tracy, Rose Charles E. Jr., Martin Stacey W., Vaccine . 2014,第28期

机译：在CDC AVA人类临床试验中评估炭疽疫苗吸附后注射部位不良事件的性别，种族，体重指数和疫苗接种前血清孕酮水平以及疫苗接种后血清抗炭疽保护性免疫球蛋白G的评估
3. Monitoring of ELISA-reactive antibodies against anthrax protective antigen (PA), lethal factor (LF), and toxin-neutralising antibodies in serum of individuals vaccinated against anthrax with the PA-based UK anthrax vaccine [J] . Grunow R, Porsch-Ozcurumez M, Splettstoesser W, Vaccine . 2007,第18期

机译：监测使用基于PA的UK炭疽疫苗接种炭疽疫苗的个体血清中针对炭疽保护性抗原（PA），致死因子（LF）和毒素中和抗体的ELISA反应性抗体
4. Efficient Acquisition of Antigen-Specific Human Monoclonal Antibody by Using Peripheral Blood Mononuclear Cells Immunized In Vitro Efficient Cloning of Human Monoclonal Antibody Gene [C] . Shinei Matsumoto, Makiko Yamashita, Yoshinori Katakura, Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：通过使用在体外克隆人单克隆抗体基因的体外克隆的外周血单核细胞高效采集抗原特异性人单克隆抗体
5. Development and characterization of a neutralizing chimeric murine-human IgG1/kappa monoclonal antibody to the protective antigen toxin of Bacillus anthracis. [D] . Boese, Darren Jacob. 2009

机译：抗炭疽芽孢杆菌保护性抗原毒素的中和嵌合鼠-人IgG1 / kappa单克隆抗体的开发和表征。
6. Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed [O] . 2004

机译：人源抗炭疽保护性抗原中和单克隆抗体，来自接种炭疽疫苗的供体
7. Protective Antigen (PA) and Toxin Neutralization (TNA) Antibody Patterns in Anthrax Vaccinees Undergoing Serial Plasmapheresis [R] . Pitman, P. R. , Leitman, S. F. , Barrera-Oro, J. G. , 2005

机译：炭疽疫苗接种系列血浆置换中的抗原（pa）和毒素中和（TNa）抗体模式

Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed

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