Induction of Squamous Metaplasia Dysplasia and Carcinoma in situ of the Mouse Tracheal Mucosa by Inhalation of Sodium Chloride Mist Following Subcutaneous Injection of 4‐Nitroquinoline 1‐Oxide

摘要

Squamous metaplasia, dysplasia and carcinoma in situ (CIS) were induced in the ICR/Jcl mouse tracheal mucosa by exposure to a mist of 5% NaCl solution following single subcutaneous injection of 4‐nitroquinoline 1‐oxide (4‐NQO). Either subcutaneous injection of 4‐NQO or NaCl inhalation alone did not cause any marked change in the tracheal mucosa. The NaCl inhalation is considered to have promotion‐like action on the mouse tracheal mucosa after administration of 4‐NQO injection.