Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis

摘要

BackgroundSepsis continues to be a poorly understood syndrome with a high mortality rate. While we are beginning to decipher the intricate interplay of the inflammatory response during sepsis, the precise regulation of the hypothalamic-pituitary-adrenal (HPA) axis and its impact on electrolyte homeostasis during sepsis remains incompletely understood.