The efficacy pharmacokinetics safety and cardiovascular risks of switching nevirapine to rilpivirine in HIV-1 patients: the RPV switch study

机译：RPV转换研究在HIV-1患者中将奈韦拉平转换为利比韦林的功效药代动力学安全性和心血管风险：

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IntroductionNevirapine (NVP) induces cytochrome P450 3A4 by which rilpivirine (RPV) is metabolized. Switching NVP to RPV could result in decreased RPV exposure with subsequent virological failure and dyslipidemia because NVP is regarded as the least dyslipidemic, non-nucleoside, reverse transcriptase inhibitor. This trial evaluated the efficacy, pharmacokinetics, safety and cardiovascular risks of switching NVP to RPV.

机译：简介奈维拉平（NVP）诱导细胞色素P450 3A4代谢，利福韦林（RPV）通过细胞色素P450 3A4代谢。将NVP转换为RPV可能会导致RPV暴露减少，并随之导致病毒学衰竭和血脂异常，因为NVP被认为是血脂异常，非核苷，逆转录酶抑制剂最少。该试验评估了将NVP改为RPV的功效，药代动力学，安全性和心血管风险。

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期刊名称 Journal of the International AIDS Society
作者
Casper Rokx; Maren Blonk; Annelies Verbon; David Burger; Bart JA Rijnders;
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年(卷),期 2014(17),4Suppl 3
年度 2014
页码 19789
总页数 1
原文格式 PDF
正文语种
中图分类免疫学;病毒传染病;
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专利

1. The efficacy, pharmacokinetics, safety and cardiovascular risks of switching nevirapine to rilpivirine in HIV-1 patients: the RPV switch study [J] . Casper Rokx, Maren Blonk, Annelies Verbon, Journal of the International Aids Society . 2014,第4Suppla3期

机译：RPV转换研究在HIV-1患者中将奈韦拉平转换为利比韦林的功效，药代动力学，安全性和心血管风险：
2. Short Communication: Lipids and Cardiovascular Risk After Switching HIV-1 Patients on Nevirapine and Emtricitabine/Tenofovir-DF to Rilpivirine/Emtricitabine/Tenofovir-DF [J] . Rokx Casper, Verbon Annelies, Rijnders Bart J. A. AIDS Research and Human Retroviruses . 2015,第4期

机译：简短交流：将使用奈韦拉平和恩曲他滨/替诺福韦-DF的HIV-1患者换用利必韦林/恩曲他滨/替诺福韦-DF的HIV-1患者后的血脂和心血管风险
3. Short Communication: Lipids and Cardiovascular Risk After Switching HIV-1 Patients on Nevirapine and Emtricitabine/Tenofovir-DF to Rilpivirine/Emtricitabine/Tenofovir-DF [J] . Rokx Casper, Verbon Annelies, Rijnders Bart J. A. AIDS Research and Human Retroviruses . 2015,第4期

机译：短期通信：将HIV-1患者及腹腔内的HIV-1患者和替尼昔韦洛-DF转换为瑞培/ EMTRICRABINE / TENOFOVIR-DF后脂质和心血管风险
4. A STUDY ON THE EFFICACY OF REGULAR VIRTUAL TOPOLOGY DESIGN HEURISTICS FOR OPTICAL PACKET SWITCHING [C] . Olufemi Komolafe, David HarLe, David Cotter, IFIP TC6/WG6.10 working conference on optical network design and modelling . 2003

机译：常规虚拟拓扑设计启发式光学包切换效能研究
5. Genetic Switching During Protein Synthesis and the Role of Quadruplexes in HIV-1's Nef Gene [D] . Cochran, Steven Nicholas 2018

机译：蛋白质合成过程中的遗传转换和HIV-1 Nef基因中四链体的作用
6. 538A Retrospective Study to Evaluate the Safety of Switching Antiretroviral Therapy (ART) to Rilpivirine/Tenofovir Disoproxil Fumarate/Emtricitabine (RPV/TDF/FTC) STR in Virologically Suppressed HIV-Infected Patients [O] . Ana Monczor, Xiaoying Yu, Karen J. Vigil, 2014

机译：538A回顾性研究评估在病毒学上受抑制的HIV感染患者中将抗逆转录病毒疗法（ART）改用Rilpivirine / Tenofovir Disoproxil Fumarate / Emtricitabine（RPV / TDF / FTC）STR的安全性
7. The efficacy, pharmacokinetics, safety and cardiovascular risks of switching nevirapine to rilpivirine in HIV-1 patients: the RPV switch study [O] . Casper Rokx, Maren Blonk, Annelies Verbon, 2014

机译：在HIV-1患者中将奈韦拉平转换为利培韦林的疗效，药代动力学，安全性和心血管风险：RpV转换研究

The efficacy pharmacokinetics safety and cardiovascular risks of switching nevirapine to rilpivirine in HIV-1 patients: the RPV switch study

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