Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients

机译：钙激活钾通道内皮小/中导的失活有助于糖尿病患者冠状动脉功能障碍。

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BackgroundDiabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SKCa/IKCa) conductance of calcium-activated potassium channels in diabetes-related endothelial dysfunction.

机译：背景糖尿病与冠状小动脉内皮功能障碍有关。我们调查了钙激活的钾通道的小/中级（SKCa / IKCa）电导在糖尿病相关的内皮功能障碍中的作用。

著录项

期刊名称 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
作者
Yuhong Liu; An Xie; Arun K Singh; Afshin Ehsan; Gaurav Choudhary; Samuel Dudley; Frank W Sellke; Jun Feng;
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作者单位

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年(卷),期 2015(4),8
年度 2015
页码 e002062
总页数 9
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
coronary microcirculation coronary microvascular function diabetes mellitus potassium channels vascular endothelial function;

机译：冠状动脉微循环;冠状动脉微血管功能;糖尿病;钾通道;血管内皮功能;

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专利

1. Inactivation of Endothelial Small/Intermediate Conductance of Calcium‐Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients [J] . Afshin Ehsan, An Xie, Arun K. Singh, Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease . 2015,第2期

机译：钙激活钾通道的内皮小/中导性失活导致糖尿病患者冠状动脉功能障碍
2. Pitavastatin inhibits upregulation of intermediate conductance calcium-activated potassium channels and coronary arteriolar remodeling induced by long-term blockade of nitric oxide synthesis. [J] . Terata Y, Saito T, Fujiwara Y, Pharmacology: International Journal of Experimental and Clinical Pharmacology . 2003,第4期

机译：匹伐他汀可抑制由一氧化氮合成的长期阻滞引起的中导钙激活钾通道和冠状动脉小动脉重构的上调。
3. Obesity up-regulates intermediate conductance calcium-activated potassium channels and myoendothelial gap junctions to maintain endothelial vasodilator function. [J] . Chadha PS, Haddock RE, Howitt L, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2010,第2期

机译：肥胖症会上调电导钙激活的钾离子通道和肌内皮间隙连接，以维持内皮血管舒张功能。
4. Coronary autoregulation based on oxygen flow: a model of oxygen supply to coronary arteriolar smooth muscle in injury and endothelial dysfunction [C] . N. Sheffer, M. Scheinowitz, O. Barnea Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2001

机译：基于氧气流动的冠状动脉自动调节：冠状动脉冠状动脉的含氧型号，损伤和内皮功能障碍
5. Single-channel kinetics of external tetraethylammonium block of large-conductance calcium-activated potassium channels. [D] . Hogan, Catherine Leigh. 1999

机译：大电导钙激活钾通道的外部四乙基铵嵌段的单通道动力学。
6. TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery [O] . C J Garland, S V Smirnov, P Bagher, 2015

机译：TRPM4抑制剂9-菲咯啉激活大鼠离体肠系膜动脉的内皮细胞中间电导钙激活的钾通道
7. TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery [O] . Garland C J, Smirnov Sergey, Bagher P, 2015

机译：TRPM4抑制剂9-菲咯啉激活大鼠离体肠系膜动脉的内皮细胞中间电导钙激活的钾通道
8. Small and Intermediate Conductance, Calcium-Activated Potassium Channels and Uses Thereof. [R] . Adelman, J. P., Maylic, J., Bond, C. T., 2005

机译：中小电导，钙激活钾通道及其用途。

Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients

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