Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinsons Disease

机译：阿扑吗啡皮下注射治疗帕金森氏病的晨运动

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BackgroundIn patients with motor fluctuations complicating Parkinson's disease (PD), delays in time‐to‐ON with levodopa are common. This open‐label study aimed to assess the effect of apomorphine on time‐to‐ON in PD patients with morning akinesia.

机译：背景在运动波动并发帕金森氏病（PD）的患者中，左旋多巴延迟上班时间很常见。这项开放标签研究旨在评估阿扑吗啡对PD患者晨起运动缺乏的影响。

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期刊名称 Movement Disorders Clinical Practice
作者
Stuart Isaacson; Mark Lew; William Ondo; Jean Hubble; Thomas Clinch; Fernando Pagan;
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作者单位

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年(卷),期 2017(4),1
年度 2017
页码 78–83
总页数 6
原文格式 PDF
正文语种
中图分类 G804.5;
关键词
apomorphine Parkinsons disease morning akinesia l‐dopa;

机译：阿扑吗啡;帕金森氏病;早晨运动障碍;左旋多巴;

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专利

1. Open-label study assessment of safety and adverse effects of subcutaneous apomorphine injections in treating "off" episodes in advanced Parkinson disease. [J] . LeWitt PA, Ondo WG, Van Lunen B, Clinical neuropharmacology . 2009,第2期

机译：开放标签研究评估了皮下注射阿扑吗啡在治疗晚期帕金森氏病中“关闭”发作的安全性和不良反应。
2. Subcutaneous apomorphine injections as a treatment for intractable pain in Parkinson's disease. [J] . Factor SA, Brown DL, Molho ES Movement disorders . 2000,第1期

机译：皮下注射阿扑吗啡可治疗帕金森氏症顽固性疼痛。
3. Dose response and concentration response relationship of apomorphine in patients with Parkinson's disease and end-of-dose akinesia. [J] . Harder S, Baas H, Demisch L, International journal of clinical pharmacology and therapeutics . 1998,第7期

机译：阿朴吗啡在帕金森氏病和剂量终止运动障碍患者中的剂量反应和浓度反应关系。
4. Computer-Based Assessment of Bradykinesia, Akinesia and Rigidity in Parkinson's Disease [C] . Laura Cunningham, Chris Nugent, George Moore, International Conference on Smart Homes and Health Telematics . 2009

机译：基于计算机的Bradykinesia，Akinesia和刚性帕金森病的评估
5. Effects of two Parkinson's disease patient education models on disease self -management and quality of life [D] . Pearl-Kraus, Lorraine 2007

机译：两种帕金森氏病患者教育模式对疾病自我管理和生活质量的影响
6. Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson’s disease [O] . Felix Agbo, Ryan L. Crass, Yu‐Yuan Chiu, 2021

机译：在健康受试者和帕金森病的患者中血管甲肽舌下胶片或皮下翼柳胺的人口药代动力学分析
7. Pharmacokinetics and Comparative Bioavailability of Apomorphine Sublingual Film and Subcutaneous Apomorphine Formulations in Patients with Parkinson’s Disease and “OFF” Episodes: Results of a Randomized, Three-Way Crossover, Open-Label Study [O] . Felix Agbo, Stuart H. Isaacson, Ramon Gil, 2021

机译：帕金森病患者Abomerphine舌下胶片和皮下扑梅啡配方的药代动力学和对比生物利用度和“关闭”集：随机，三通交叉，开放标签研究的结果

Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinsons Disease

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