Rapid kit-based 68Ga-labelling and PET imaging with THP-Tyr3-octreotate: a preliminary comparison with DOTA-Tyr3-octreotate

摘要

BackgroundGe/⁶⁸Ga generators provide an inexpensive source of a PET isotope to hospitals without cyclotron facilities. The development of new ⁶⁸Ga-based molecular imaging agents and subsequent clinical translation would be greatly facilitated by simplification of radiochemical syntheses. We report the properties of a tris(hydroxypyridinone) conjugate of the SSTR2-targeted peptide, Tyr³-octreotate (TATE), and compare the ⁶⁸Ga-labelling and biodistribution of [⁶⁸Ga(THP-TATE)] with the clinical radiopharmaceutical [⁶⁸Ga(DOTATATE)].