Total Synthesis of Lignan Lactone (–)-Hinokinin

摘要

This research paper is aimed at studying the total synthesis of pharmacologically active lignan (–)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate.Electronic supplementary materialThe online version of this article (doi:10.1007/s13659-015-0073-3) contains supplementary material, which is available to authorized users.