Increased thalamic centrality and putamen–thalamic connectivity in patients with parkinsonian resting tremor

摘要

IntroductionEvidence has indicated a strong association between hyperactivity in the cerebello‐thalamo‐motor cortical loop and resting tremor in Parkinson's disease (PD). Within this loop, the thalamus serves as a central hub based on its structural centrality in the generation of resting tremor. To study whether this thalamic abnormality leads to an alteration at the whole‐brain level, our study investigated the role of the thalamus in patients with parkinsonian resting tremor in a large‐scale brain network context.