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Utilization of a 3D printer to fabricate boluses used for electron therapy of skin lesions of the eye canthi

机译:利用3D打印机制造用于眼睑皮肤病变电子治疗的大剂量药物

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摘要

This work describes the use of 3D printing technology to create individualized boluses for patients treated with electron beam therapy for skin lesions of the eye canthi. It aimed to demonstrate the effectiveness of 3D‐printed over manually fabricated paraffin boluses. The study involved 11 patients for whom the construction of individual boluses were required. CT scans of the fabricated 3D‐printed boluses and paraffin boluses were acquired and superimposed onto patient CT scans to compare their fitting, bolus homogeneity, and underlying dose distribution. To quantify the level of matching, multiple metrics were utilized. Matching Level Index (ML) values ranged from 0 to 100%, where 100% indicated a perfect fit between the reference bolus (planned in treatment planning system) and 3D‐printed and paraffin bolus. The average ML (± 1 SD) of the 3D‐printed boluses was 95.1 ± 2.1%, compared to 46.0 ± 10.1% for the manually fabricated paraffin bolus. Correspondingly, mean doses were closer to the prescribed doses, and dose spreads were less for the dose distributions from the 3D‐printed boluses, as compared to those for the manually fabricated paraffin boluses. It was concluded that 3D‐printing technology is a viable method for fabricating boluses for small eye lesions and provides boluses superior to our boluses manually fabricated from paraffin sheets.
机译:这项工作描述了使用3D打印技术为接受电子束治疗眼睑皮肤病变的患者创建个性化的大剂量药物的方法。它旨在证明3D打印优于手工制作的石蜡丸剂的有效性。该研究涉及11名患者,他们需要构建单独的弹丸。采集了3D打印的大剂量和石蜡大剂量的CT扫描,并将其叠加在患者的CT扫描上,以比较其拟合度,大剂量均匀性和基础剂量分布​​。为了量化匹配级别,使用了多个指标。匹配水平指数(ML)值的范围从0到100%,其中100%表示参考推注(在治疗计划系统中计划)与3D打印和石蜡推注之间的完美契合。 3D打印推注的平均ML(±1 SD)为95.1±2.1%,相比之下,手工制作的石蜡推注的平均ML(±1 SD)为46.0±10.1%。相应地,与手工制作的石蜡丸剂相比,3D打印丸剂的剂量分布的平均剂量更接近规定剂量,并且剂量分布较小。结论是3D打印技术是一种用于制造眼部小损伤的小剂量药丸的可行方法,并且其药丸优于我们用石蜡片手工制作的小丸剂。

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