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Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers

机译：工程化抗路易斯-Y hu3S193抗体可提高上皮癌放射免疫疗法的治疗率

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BackgroundThe aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery.

机译：背景研究的目的是探索人源化抗刘易斯Y抗体（IgG1）hu3S193的Fc突变，作为提高治疗有效载荷递送治疗率的策略。

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期刊名称 EJNMMI Research
作者
Ingrid J. G. Burvenich; Fook-Thean Lee; Graeme J. O’Keefe; Dahna Makris; Diana Cao; Sylvia Gong; Angela Rigopoulos; Laura C. Allan; Martin W. Brechbiel; Zhanqi Liu; Paul A. Ramsland; Andrew M. Scott;
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年(卷),期 2016(6),-1
年度 2016
页码 26
总页数 13
原文格式 PDF
正文语种
中图分类
关键词
Therapeutic ratio Payload delivery Antibody engineering Small animal imaging Lewis-Y;

机译：治疗比率;有效载荷输送;抗体工程;小动物成像;Lewis-Y;

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专利

1. Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers [J] . Ingrid J. G. Burvenich, Fook-Thean Lee, Graeme J. O’Keefe, EJNMMI Research . 2016,第Suppla1期

机译：工程化抗路易斯-Y hu3S193抗体，具有上皮癌放射免疫疗法更高的治疗率
2. Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering [J] . Yu Xiaojie, Marshall Michael J. E., Cragg Mark S., BioDrugs: Clinical immunotherapeutics, biopharmaceuticals, and gene therapy . 2017,第3期

机译：通过聚糖工程改善基于抗体的癌症治疗方法
3. Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure [J] . Chow Chi-Kin, Allan Barrett W., Chai Qing, Molecular pharmaceutics . 2016,第3期

机译：晶体结构指导的提高粘度和相分离的治疗性抗体工程
4. Cancer Immunotherapy Based on Engineered Novel Antibodies to Treat Cancers and Build Better Therapeutics [C] . Yanling Wu, Tianlei Ying PEGS . 2016

机译：基于工程新颖的抗体治疗癌症的癌症免疫疗法，并构建更好的治疗方法
5. Copper-64-labeled antibodies for the radioimmunotherapy of colon cancer in a mouse model [D] . Bryan, Jeffrey N. 2004

机译：铜64标记的抗体可在小鼠模型中进行结肠癌的放射免疫治疗
6. Treating Bladder Cancer: Engineering of Current and Next Generation Antibody- Fusion Protein- mRNA- Cell- and Viral-Based Therapeutics [O] . Jan P. Bogen, Julius Grzeschik, Joern Jakobsen, 2021

机译：治疗膀胱癌：当前和下一代抗体的工程融合蛋白mRNA细胞和病毒的治疗方法
7. Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers [O] . 2016

机译：工程化抗路易斯-Y hu3S193抗体，可提高上皮癌放射免疫疗法的治疗率
8. Radioimmunotherapy (RIT) Dose-Escalation Studies in Prostate Cancer Using Anti-PSMA Antibody 177Lu-J591: RIT Alone and RIT in Combination with Docetaxel [R] . Vallabhajosula, S. 2010

机译：使用抗psma抗体177Lu-J591的前列腺癌的放射免疫疗法（RIT）剂量 - 升级研究：RIT单独和RIT与多西紫杉醇组合

Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers

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