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Monitoring deep inspiration breath hold for left‐sided localized breast cancer radiotherapy with an in‐house developed laser distance meter system

机译:使用内部开发的激光测距仪系统监测深吸气屏息以进行左侧局部乳腺癌放疗

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摘要

Deep inspiration breath hold (DIBH) in left‐sided breast cancer radiotherapy is a technique to reduce cardiac and pulmonary doses while maintaining target coverage. This study aims at evaluating an in‐house developed DIBH system. Free‐breathing (FB) and DIBH plans were generated for 22 left‐sided localized breast cancer patients who had radiation therapy (RT) after breast‐conserving surgery. All patients were treated utilizing an in‐house laser distance measuring system. 50 Gy was prescribed, and parameters of interest were target coverage, left anterior descending coronary artery, (LAD) and heart doses. Portal images were acquired and the reproducibility and stability of DIBH treatment were compared to FB. The comparing result shows there is a significant reduction in all LAD and heart dose statistics for DIBH compared to FB plans without compromising the target coverage. The maximum LAD dose was reduced from 43.7 Gy to 29.0 Gy and the volume of the heart receiving >25 Gy was reduced from 3.3% to 1.0% using the in‐house system, both statistically significant. The in‐house system gave a reproducible and stable DIBH treatment where the systematic error ∑, and random error σ, were less than 2.2 mm in all directions, but were not significantly better than at FB. The system was well tolerated and all patients completed their treatment sessions with DIBH.
机译:左侧乳腺癌放疗中的深吸气屏气(DIBH)是一种在保持目标覆盖范围的同时减少心脏和肺部剂量的技术。本研究旨在评估内部开发的DIBH系统。为22位在保乳手术后接受放疗(RT)的左侧局部乳腺癌患者制定了自由呼吸(FB)和DIBH计划。所有患者均使用内部激光测距系统进行了治疗。开处方50 Gy,感兴趣的参数是靶标覆盖率,左前降支冠状动脉(LAD)和心脏剂量。获取门静脉图像,并将DIBH处理的重现性和稳定性与FB进行比较。比较结果表明,与FB计划相比,DIBH的所有LAD和心脏剂量统计数据均显着减少,而没有损害目标覆盖率。使用内部系统,最大LAD剂量从43.7Gy降低到29.0Gy,接受大于25Gy的心脏的体积从3.3%降低到1.0%,两者在统计上均显着。内部系统提供了可重现且稳定的DIBH处理,其中系统误差∑和随机误差σ在各个方向上均小于2.2 mm,但并没有明显好于FB。该系统耐受良好,所有患者均完成了DIBH的治疗。

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