Design and rationale for the DIVERSITY study: An open‐label randomized study of dabigatran etexilate for pediatric venous thromboembolism

机译：DIVERSITY研究的设计和原理：达比加群酯对儿科静脉血栓栓塞的开放性随机研究

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Essentials class="unordered" style="list-style-type:disc" id="rth212086-list-0001">Current standard of care (SOC) for pediatric venous thromboembolism (VTE) has limitations.Dabigatran etexilate (DE) versus SOC will be studied in children with VTE in a phase IIb/III trial.A dosing algorithm for DE in children will be assessed guiding dosing.Valuable data on the safety and efficacy of DE for VTE in children will be obtained.

机译：要点 class =“ unordered” style =“ list-style-type：disc” id =“ rth212086-list-0001”> <！-list-behavior = unordered prefix-word = mark-type = disc max-label -size = 0-> 小儿静脉血栓栓塞（VTE）的当前护理标准（SOC）有局限性。达比加群酯（DE）与SOC的关系将在VTE儿童中进行IIb / III期临床试验。将对儿童DE的给药算法进行评估以指导给药。将获得有关儿童VTE的DE安全性和有效性的重要数据。

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期刊名称 Research and Practice in Thrombosis and Haemostasis
作者
Manuela Albisetti; Branislav Biss; Lisa Bomgaars; Leonardo R. Brandão; Martina Brueckmann; Elizabeth Chalmers; Savion Gropper; Ruth Harper; Fenglei Huang; Matteo Luciani; Ivan Manastirski; Lesley G. Mitchell; Igor Tartakovsky; Bushi Wang; Jacqueline M. L. Halton;
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年(卷),期 2018(2),2
年度 2018
页码 347–356
总页数 10
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
anticoagulants dabigatran etexilate direct thrombin inhibitors pediatrics venous thromboembolism;

机译：抗凝剂;达比加群酯;直接凝血酶抑制剂;儿科;静脉血栓栓塞;

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1. Design and rationale for the DIVERSITY study: An open‐label, randomized study of dabigatran etexilate for pediatric venous thromboembolism [J] . Manuela Albisetti, Branislav Biss, Lisa Bomgaars, Research and practice in thrombosis and haemostasis. . 2018,第2期

机译：DIVERSITY研究的设计和依据：达比加群酯对小儿静脉血栓栓塞的开放性随机研究
2. Phase 3, single‐arm, multicenter study of dabigatran etexilate for secondary prevention of venous thromboembolism in children: Rationale and design [J] . Matteo Luciani, Manuela Albisetti, Branislav Biss, Research and practice in thrombosis and haemostasis. . 2018,第3期

机译：dabigatran etexilate用于儿童静脉血栓栓塞的二级预防的第3期单臂，多中心研究：原理和设计
3. Rationale and design of a phase III safety trial of idarucizumab in children receiving dabigatran etexilate for venous thromboembolism [J] . Albisetti Manuela, Schlosser Arno, Brueckmann Martina, Research and practice in thrombosis and haemostasis. . 2018,第1期

机译：依达珠单抗治疗接受达比加群酯治疗静脉血栓栓塞的儿童的III期安全性试验的原理和设计
4. Fiber-based label-free D-dimer detection for early diagnosis of venous thromboembolism [C] . P.Zubiate, A.Urrutia, C.R.Zamarreno, Conference on Optical Sensing and Detection . 2020

机译：基于纤维的无标记D-二聚体检测可早期诊断静脉血栓栓塞
5. A randomized, open-label, intervention study to evaluate the effect of diet composition on weight gain in obese, type 2 diabetes patients receiving intensive insulin therapy. [D] . Villareal, Roland. 2008

机译：一项随机，开放标签，干预性研究，以评估饮食结构对接受强化胰岛素治疗的肥胖2型糖尿病患者体重增加的影响。
6. Phase 3 single‐arm multicenter study of dabigatran etexilate for secondary prevention of venous thromboembolism in children: Rationale and design [O] . Matteo Luciani, Manuela Albisetti, Branislav Biss, 2018

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7. Design and Rationale of the RE-DUAL PCI Trial : A Prospective, Randomized, Phase 3b Study Comparing the Safety and Efficacy of Dual Antithrombotic Therapy With Dabigatran Etexilate Versus Warfarin Triple Therapy in Patients With Nonvalvular Atrial Fibrillation Who Have Undergone Percutaneous Coronary Intervention With Stenting [O] . Cannon, Christopher P., Gropper, Savion, Bhatt, Deepak L., 2016

机译：RE-DUAL PCI试验的设计和理论基础：一项前瞻性，随机，3b期研究，比较了接受经皮冠状动脉介入治疗并接受支架置入术的非瓣膜性心房颤动双重抗栓治疗与达比加群酯对华法林三联疗法的安全性和有效性

Design and rationale for the DIVERSITY study: An open‐label randomized study of dabigatran etexilate for pediatric venous thromboembolism

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