The “14‐day rule”—broadly construed—is used in science policy and regulation to limit research on human embryos to a maximum period of 14 days after their creation or to the equivalent stage of development that is normally attributed to a 14‐day‐old embryo (Hyun et al, ; Nuffield Council on Bioethics, ). For several decades, the 14‐day rule has been a shining example of how science policy and regulation can be developed with interdisciplinary consensus and applied across a number of countries to help fulfil an ethical and practical purpose: to facilitate efficient and ethical embryo research. However, advances in embryology and biomedical research have led to suggestions that the 14‐day rule is no longer adequate (Deglincerti et al, ; Shahbazi et al, ; Hurlbut et al, ). Therefore, should the 14‐day rule be extended and, if so, where should we draw a new line for permissible embryo research? Here, we provide scientific, regulatory and ethical arguments that the 14‐day rule should be extended to 28 days (or the developmental equivalent stage of a 28‐day‐old embryo).
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机译：广泛解释的“ 14天规则”在科学政策和法规中用于将对人类胚胎的研究限制在其创建后最多14天或通常归因于14天的等效发育阶段胚胎（Hyun et al .; Nuffield Council on Bioethics，）。几十年来，为期14天的规则一直是如何在跨学科共识的基础上制定科学政策和法规并在许多国家/地区应用的光辉典范，以帮助实现道德和实践目的：促进高效和道德的胚胎研究。但是，随着胚胎学和生物医学研究的进展，人们提出了14天规则不再适用的建议（Deglincerti等，Shahbazi等，Hurlbut等）。因此，应该延长14天规则，如果这样，我们应该在哪里为允许的胚胎研究画一条新线？在这里，我们提供科学，法规和道德方面的论据，认为14天规则应延长至28天（或28天龄胚胎的发育等效阶段）。
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