Hereditary cancer screening: Case reports and review of literature on ten Ashkenazi Jewish founder mutations

摘要

BackgroundHistorically, three founder mutations in the BRCA1/2 (OMIM 113705; OMIM 600185) genes have been the focus of cancer risks within the Ashkenazi Jewish (AJ) population. However, there are several additional mutations associated with increased susceptibility to cancer in individuals of AJ ancestry.