Food‐effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

机译：尿嘧啶和二氢尿嘧啶血浆水平作为人类志愿者中二氢嘧啶脱氢酶活性的标志物的食物效应研究

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摘要

AimsThis study aimed to determine the effect of food intake on uracil and dihydrouracil plasma levels. These levels are a promising marker for dihydropyrimidine dehydrogenase activity and for individualizing fluoropyrimidine anticancer therapy.

机译：目的这项研究旨在确定食物摄入对尿嘧啶和二氢尿嘧啶血浆水平的影响。这些水平是二氢嘧啶脱氢酶活性和个体化氟嘧啶抗癌治疗的有前途的标志物。

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期刊名称 British Journal of Clinical Pharmacology
作者
Linda M. Henricks; Bart A. W. Jacobs; Didier Meulendijks; Dick Pluim; Daan van den Broek; Niels de Vries; Hilde Rosing; Jos H. Beijnen; Alwin D. R. Huitema; Henk‐Jan Guchelaar; Annemieke Cats; Jan H. M. Schellens;
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作者单位

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年(卷),期 2018(84),12
年度 2018
页码 2761–2769
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
dihydropyrimidine dehydrogenase dihydrouracil food‐effect study uracil uridine;

机译：二氢嘧啶脱氢酶;二氢尿嘧啶;食物效应研究;尿嘧啶;尿苷;
入库时间 2022-08-21 11:01:23

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专利

1. Food‐effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers [J] . Linda M. Henricks, Bart A. W. Jacobs, Didier Meulendijks, British journal of clinical pharmacology . 2018,第12期

机译：尿嘧啶和二氢尿嘧啶血浆水平作为人类志愿者中二氢嘧啶脱氢酶活性的标志物的食物效应研究
2. Food‐effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers [J] . Henricks Linda M., Jacobs Bart A. W., Meulendijks Didier, British Journal of Clinical Pharmacology . 2018,第12期

机译：尿嘧啶和二氢尿嘧啶血浆水平作为人类志愿者二氢嘧啶脱氢酶活性的尿嘧啶和二氢尿嘧啶水平的食物效应研究
3. Association between the pharmacokinetics of capecitabine and the plasma dihydrouracil to uracil ratio in rat: A surrogate biomarker for dihydropyrimidine dehydrogenase activity [J] . Kobuchi Shinji, Akutagawa Mako, Ito Yukako, Biopharmaceutics and Drug Disposition . 2019,第1期

机译：Capecitabine的药代动力学与大鼠尿嘧啶比的血浆二氢嘧啶之间的关系：二氢嘧啶脱氢酶活性的替代生物标志物
4. Thymidine Phosphorylase (TP) and Dihydropyrimidine Dehydrogenase (DPD) in Colorectal Cancer: Gene Expressions Level vs. Protein Level [C] . J. Sobajima, T. Gonda, T. Oosawa, International Society of University Colon and Rectal Surgeons . 2006

机译：结直肠癌中胸苷磷酸化酶（TP）和二氢嘧啶脱氢酶（DPD）：基因表达水平与蛋白质水平
5. Development, validation, and use of a novel [2-carbon-13] uracil breath test to detect dihydropyrimidine dehydrogenase deficiency. [D] . Mattison, Lori K. 2006

机译：开发，验证和新型的[2-carbon-13]尿嘧啶呼气试验来检测二氢嘧啶脱氢酶缺乏症。
6. Circadian rhythm of dihydrouracil/uracil ratios in biological fluids: a potential biomarker for dihydropyrimidine dehydrogenase levels [O] . Hao Jiang, Jing Lu, Jiang Ji 2004

机译：生物体液中二氢尿嘧啶/尿嘧啶比率的昼夜节律：二氢嘧啶脱氢酶水平的潜在生物标志物
7. Circadian rhythm of dihydrouracil/uracil ratios in biological fluids: a potential biomarker for dihydropyrimidine dehydrogenase levels [O] . Jiang, Hao, Lu, Jing, Ji, Jiang 2004

机译：生物体液中二氢尿嘧啶/尿嘧啶比率的昼夜节律：二氢嘧啶脱氢酶水平的潜在生物标志物

Food‐effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

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