Performance Verification of the Accelerate Pheno™ System for Rapid Identification and Antimicrobial Susceptibility Testing from Positive Blood Culture in a Pediatric Population

摘要

BackgroundEarly targeted antibiotic therapy is crucial when treating pediatric patients with bacteremia. While identification (ID) and antimicrobial susceptibility testing (AST) of bloodstream pathogens are critical to optimizing therapy, conventional methods can take days resulting in inappropriate use of broad-spectrum antibiotics. The automated Accelerate Pheno™ system (AXDX) provides ID in <90 minutes and AST in <7 hours directly from positive blood culture (PBC), enabling clinicians to optimize antibiotic therapy sooner to improve patient outcomes. In addition, the unique AXDX Monomicrobial call effectively rules out polymicrobial samples by indicating only one bacteria is present in the PBC. This study verifies AXDX performance compared with current laboratory ID and AST methods.