In vitro Activity of Cefiderocol against Globally Collected Carbapenem-Resistant Gram-Negative Bacteria Isolated from Urinary Track Source: SIDERO-CR-2014/2016

摘要

BackgroundCefiderocol (S-649266) is a novel siderophore cephalosporin active against a wide variety of Gram-negative bacteria, not only Enterobacteriaceae but also non-fermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter spp., including carbapenem-resistant strains. This potent activity is due to its efficient penetration through the outer membrane via active iron transporter systems and its high stability to both serine- and metallo-carbapenemases.This study evaluated the in vitro activity of cefiderocol and comparator agents against carbapenem-resistant clinical isolates collected from urinary track source in 2014–2016 from global countries.