The Impact of Hepatitis C Virus (HCV) Treatment with Direct-Acting (DAA) on the Incidence of Hepatocellular Carcinoma (HCC) in Patients with Advanced Liver Disease

摘要

Background Use DAA has resulted in widespread eradication of Hepatitis C virus (HCV) infection in patients with advanced liver disease (ALD) compared with interferon (IFN)-based treatment era therapy. Recent reports have indicated an increased risk of hepatocellular carcinoma (HCC) associated with HCV treatment with DAA and/or after achieving sustained virologic response (SVR). Decreasing incidence of HCC has been reported for patients treated with IFN-based therapy who achieve SVR. Widespread HCV treatment with IFN-based therapy was started in 2006 at a single center. An interest exist whether there was an increase in HCC incidence after introduction of DAA therapy.