T138. ACOUSTIC PATTERNS IN SCHIZOPHRENIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

摘要

BackgroundIndividuals with schizophrenia are characterized as presenting atypical voice patterns: poverty of speech, increased pauses, distinctive pitch (mean and variability). Voice atypicalities may play a role in the social impairment experienced by patients, and could constitute a window into motor, cognitive, emotional and social components of the disorder. Indeed, they have already been generally associated with negative symptoms. However, the state of the evidence for atypical voice patterns and their relation to clinical features is uncertain. Studies using clinical rating scales indicate that voice alterations are severe across many voice properties. In contrast, quantitative acoustic studies seem to have found less robust and more variable results limited to specific features. We therefore systematically reviewed the literature quantifying acoustic patterns in schizophrenia, and performed a meta-analysis of the evidence. We aimed at identifying evidence for acoustic markers of schizophrenia and its clinical features, needs for further research and barriers to collective advancements on these issues.