F251. REVISITING THE RELATIONSHIP BETWEEN NEUROCOGNITION AND SUBJECTIVE QUALITY OF LIFE IN SCHIZOPHRENIA

摘要

BackgroundNeurocognitive impairments are a major feature of schizophrenia and present long-term challenges to the quality of life (QOL) of patients. Their contribution to a patient’s life satisfaction (subjective QOL; sQOL) has been much investigated, however, results have been equivocal and often non-significant. This contrasts with relatively more evidence for the neurocognition-objective QOL (oQOL) relationship. Previous work has also not investigated any differences in the subjective QOL associations between lower-order (e.g. processing speed, attention) and higher order (e.g. executive function) cognitive abilities. This study sought to better characterise the neurocognition-sQOL relationship through 3 separate analyses in clinical and healthy control samples: 1) examining correlational relationships between oQOL and sQOL and both lower-order and executive cognitive skills; 2) examining if lower-order or executive cognitive skills moderate the relationship between oQOL and sQOL; and 3) examining if the relationship between sQOL and both lower-order and executive cognitive skills differs between groups.