Sodium butyrate and panobinostat induce apoptosis of chronic myeloid leukemia cells via multiple pathways

机译：丁酸钠和panobinostat可以通过多种途径诱导慢性髓性白血病细胞凋亡

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PurposeHistone deacetylase inhibitor (HDACI) is a novel therapeutic option for cancer. However, the effects of HDACIs on chronic myeloid leukemia (CML) and the underlying mechanisms are still unknown. The aim of this study was to investigate the effect and the mechanism‐of‐action of two HDACI members, sodium butyrate (NaBu) and panobinostat (LBH589) in K562 and the adriamycin–resistant cell line K562/ADR.

机译：目的组蛋白脱乙酰基酶抑制剂（HDACI）是一种针对癌症的新型治疗选择。但是，HDACIs对慢性粒细胞白血病（CML）的影响及其潜在机制仍然未知。这项研究的目的是研究两个HDACI成员丁酸钠（NaBu）和panobinostat（LBH589）在K562和抗阿霉素细胞株K562 / ADR中的作用及其作用机理。

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期刊名称 Molecular Genetics Genomic Medicine
作者
Xiaoyuan Jia; Yinsuo Zheng; Yanzi Guo; Kan Chen;
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作者单位

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年(卷),期 2019(7),5
年度 2019
页码 e613
总页数 11
原文格式 PDF
正文语种
中图分类遗传学;
关键词
AKT‐mTOR pathway apoptosis chronic myeloid leukemia (CML) drug resistance histone deacetylase inhibitors (HDACIs);

机译：AKT-mTOR途径;细胞凋亡;慢性粒细胞白血病（CML）;耐药性;组蛋白脱乙酰基酶抑制剂（HDACIs）;

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专利

1. Sodium butyrate and panobinostat induce apoptosis of chronic myeloid leukemia cells via multiple pathways [J] . Xiaoyuan Jia, Yinsuo Zheng, Yanzi Guo, Molecular Genetics & Genomic Medicine . 2019,第5期

机译：丁酸钠和Panobinostat通过多种途径诱导慢性骨髓白血病细胞凋亡
2. Costunolide promotes imatinib-induced apoptosis in chronic myeloid leukemia cells via the Bcr/Abl-Stat5 pathway [J] . Cai Hong, He Xiaolin, Yang Chunhui Phytotherapy research: PTR . 2018,第9期

机译：昆粒烯化剂通过BCR / ABL-Stat5途径促进慢性髓性白血病细胞中的伊马替尼诱导的细胞凋亡
3. Overexpression of miR-574-3p suppresses proliferation and induces apoptosis of chronic myeloid leukemia cells via targeting IL6/JAK/STAT3 pathway [J] . Yang Haoying, Zhang Jun, Li Jiuping, Experimental and therapeutic medicine . 2018,第5期

机译：MiR-574-3P的过度表达抑制了通过靶向IL6 / JAK / Stat3途径抑制慢性髓性白血病细胞凋亡的增殖和诱导慢性骨髓白血病细胞凋亡
4. Cytoplasmic signaling involved in sonoporation-induced apoptosis and mitosis repression of myeloid leukemia cells [C] . Zhong Wenjing, Sit Wai-Hung, Wan Jennifer M. F., 2010 IEEE International Ultrasonics Symposium . 2010

机译：细胞质信号参与声波诱导的髓样白血病细胞凋亡和有丝分裂抑制
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway [O] . Jian-Ye Zhang, Min-Ting Lin, Ho-Yi Tung, 2016

机译：芥氨酸丁酸通过线粒体途径诱导人慢性粒细胞白血病K562细胞凋亡
7. Sodium butyrate and panobinostat induce apoptosis of chronic myeloid leukemia cells via multiple pathways [O] . Xiaoyuan Jia, Yinsuo Zheng, Yanzi Guo, 2019

机译：丁酸钠和Panobinostat通过多种途径诱导慢性骨髓白血病细胞凋亡

Sodium butyrate and panobinostat induce apoptosis of chronic myeloid leukemia cells via multiple pathways

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