INDUCED PLURIPOTENT STEM CELL MODEL OF CHRONIC MYELOID LEUKEMIA REVEALED OLFACTOMEDIN 4 AS A NOVEL THERAPEUTIC TARGET IN LEUKEMIA STEM CELLS

摘要

Disclosed herein are compositions and methods to treat and reduce therapeutic resistance in chronic myelogenous leukemia. Also disclosed herein are methods to generate leukemia stem cell like cells (iLSCs) generated from CML patient-derived iPSCs, and methods for utilizing iLSCs in screens to identify modulators of CML drug resistance and gene targets that underlie CML drug resistance.